International Journal for Vitamin and Nutrition Research

Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics. The editorial and advisory boards include many of the leading persons currently working in this area.

The journal is of particular interest to:

• Nutritionists
• Vitaminologists
• Biochemists
• Physicians
• Engineers of human and animal nutrition

International Journal for Vitamin and Nutrition Research is abstracted/indexed in Science Citation Index Expanded (SCIE, Sci-Search), Current Contents/Agriculture, Biology, and Environmental Sciences, Science Citation Index, Current Contents/Life Sciences, Prous Science Integrity, Journal Citation Reports/Science Edition, Biological Abstracts, BIOSIS Previews, Medline, AGRICOLA, EMBASE, BIOBASE, EMBASE Biology, EMCARE, Scopus, CAB Abstracts and CAB Health.

Effects of Androstenedione-Herbal Supplementation on Serum Sex Hormone Concentrations in 30- to 59-Year-old Men

PDF (76 KB)

Abstract

The effectiveness of a nutritional supplement designed to enhance serum testosterone concentrations and prevent the formation of dihydrotestosterone and estrogens from the ingested androgens was investigated in healthy 30- to 59-year old men. Subjects were randomly assigned to consume DION (300 mg androstenedione, 150 mg dehydroepiandrosterone, 540 mg saw palmetto, 300 mg indole-3-carbinol, 625 mg chrysin, and 750 mg Tribulus terrestris per day; n = 28) or placebo (n = 27) for 28 days. Serum free testosterone, total testosterone, androstenedione, dihydrotestosterone, estradiol, prostate-specific antigen (PSA), and lipid concentrations were measured before and throughout the 4-week supplementation period. Serum concentrations of total testosterone and PSA were unchanged by supplementation. DION increased (p < 0.05) serum androstenedione (342%), free testosterone (38%), dihydrotestosterone (71%), and estradiol (103%) concentrations. Serum HDL-C concentrations were reduced by 5.0 mg/dL in DION (p < 0.05). Increases in serum free testosterone (r² = 0.01), androstenedione (r² = 0.01), dihydrotestosterone (r² = 0.03), or estradiol (r² = 0.07) concentrations in DION were not related to age. While the ingestion of androstenedione combined with herbal products increased serum free testosterone concentrations in older men, these herbal products did not prevent the conversion of ingested androstenedione to estradiol and dihydrotestosterone.

Key words

Androstenedione - chrysin - DHEA - dihydrotestosterone - estrogens - indole-3-carbinol - saw palmetto - testosterone - Tribulus terrestris

doi:10.1024/0300-9831.71.5.293

International Journal for Vitamin and Nutrition Research, Seite 293 - 301, Band 71, 2001, Heft 5 © Verlag Hans Huber, Bern